probe

Fiber-Optic Raman Spectroscopy

Raman-technology platform for fiber-optic tissue analysis

Enabling real-time, in vivo tissue analysis

Fiber-Optic Raman spectroscopy is an emerging technology with strong potential for real-time, in vivo tissue analysis. Applications range from direct tissue characterization and diagnostic support to endoscopic biopsy guidance and surgical guidance in open, laparoscopic, and robotic procedures. Despite this promise, widespread adoption has long been limited by the lack of suitable fiber-optic probes.

For more than two decades, the field has faced persistent challenges: available probes are often complex, costly, difficult to manufacture with consistent performance, and hard to access. These technical and practical barriers have significantly slowed development and clinical translation of Fiber-Optic Raman spectroscopy.

Overcoming hurdles

The goal of the Fiber-Optic Raman platform is to remove the technical, manufacturing, and data-processing hurdles that have historically stood in the way of real-world applications. By focusing on accessibility, reproducibility, and ease of integration, RiverD aims to accelerate innovation and enable broader adoption of Fiber-Optic Raman spectroscopy in clinical research and beyond.

Interested in high-quality, artefact-free in vivo tissue Raman spectra? We welcome collaboration and are keen to explore your applications and requirements together.

A universal Raman technology platform

RiverD is developing a universal Raman technology platform designed specifically for fiber-optic tissue analysis. The platform offers a complete, integrated solution that combines, together, these components providing a practical foundation for high-quality in vivo Raman measurements across a wide range of clinical and research settings.
A high-performance NIR-Raman module
The platform is built around a high-performance near-infrared (NIR) Raman module optimized for in vivo tissue analysis. Operating in the NIR range helps reduce tissue autofluorescence while maintaining strong Raman signal quality, enabling sensitive and reproducible measurements in challenging biological environments. The module is designed for stability and consistency, supporting reliable data acquisition during real-time, clinical-style measurements.
Miniaturized and flexible fiber-optic probes
To enable practical in vivo use, the platform includes a selection of compact and flexible fiber-optic probes that can be integrated into a wide variety of clinical and research workflows. These probes are designed with manufacturability and cost in mind, making high-quality Fiber-Optic Raman spectroscopy more accessible without compromising performance.
Customizable probe designs tailored to specific applications
Recognizing that no two applications are the same, the fiber-optic probes can be customized to meet specific requirements. This includes variations in probe geometry, length, diameter, and optical configuration, allowing integration into endoscopic tools, surgical instruments, or experimental setups. This flexibility supports use in diverse contexts such as endoscopy, laparoscopic and robotic surgery, and targeted tissue analysis.
Proprietary real-time data pre-processing for reliable, artefact-reduced spectra
Fiber-Optic Raman measurements are particularly sensitive to artefacts arising from background signals, fiber contributions, and motion. The platform incorporates proprietary real-time data pre-processing to address these challenges at the point of acquisition. By automatically reducing artefacts and improving spectral quality, the system delivers cleaner, more interpretable Raman spectra, enabling confident analysis and faster translation to practical applications.
european commission

supported by the European Innovation Council

This development is supported by the European Innovation Council’s Horizon 2020 research and innovation programme.

Our Learning center

Want to know more about our products and research? Discover the information in our learning center:
About our learning center

Your gateway to knowledge, resources, and best practices in Raman spectroscopy and skin research. Here you’ll find everything you need to deepen your understanding of our technologies, explore real-world applications, and stay informed about the latest scientific developments.

Whether you’re new to Raman-based measurements or an experienced researcher, the Learning Center brings together our tutorials, publications, brochures, and application notes in one place. Each resource is designed to support your work, help you interpret results with confidence, and make the most of RiverD’s instruments and software.

Explore our educational materials, discover new insights, and learn how RiverD’s technologies are transforming non-invasive skin analysis.

To date ~200 publication in peer-reviewed literature

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